4th BioProScale Symposium 2016

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Wednesday, April 6, 2016

13:00 Welcome address and introduction Peter Neubauer (Department of Bioprocess Engineering, TU Berlin, Germany)  
13:30 Plenary lecture: Reflections of a 40-years ripening process for modeling of bioreactors - From well mixed towards more reality (L01)
Matthias Reuss (University of Stuttgart, Germany)
Session: Industrial scale operation
Chair: Alvin Nienow (University of Birmingham, UK), Peter Neubauer (TU Berlin)   
14:15 Key note lecture: Continuous improvements in the understanding of large scale aerobic fermentation processes (L02)
Stuart Michael Stocks (Novozymes, Danmark)
14:45 Key note lecture: Large-scale production of two molecules of pharmaceutical interest in S. cerevisiae (L03)
Claus Lattemann (Sanofi, Paris, France)
15:15 Key note lecture: Microbial GMP manufacturing at large-scale - Challenges and considerations (L04)
Torsten Schmidt (Lonza, Visp, Switzerland) 
15:45 Sponsor talk: Bioprocess scale-up from small to large pilot scale using Eppendorf fermentation systems (L05)
Christof Knocke (Eppendorf Bioprocess Center, Jülich, Germany)
15:55 Coffee break and poster session and exhibition  
Session: Bioprocess and bioreactor modelling
Chair: Christoph Herwig (TU Wien, Vienna, Austria), Nicolas Cruz-Bournazou (TU Berlin)   
16:40 Key note lecture: Hybrid modelling and multi-parametric control of bioprocesses (L06)
Christoph Herwig (TU Wien, Austria)
17:00 Industrial Case Study: Data science investigations to improve bioprocess scale-up (L07)
Patrick Sagmeister (Exputec GmbH, Vienna, Austria)
17:15 Multivariate data- and knowledge-driven tools for robust and efficient cell culture process development (L08)
Michael Sokolov (ETH Zürich, Switzerland)
17:30 Implementation of computational fluid dynamics (CFD) as a Quality by Design (QbD) tool for industrial process development (L09)
Thomas Wucherpfennig (Boehringer Ingelheim Pharma, Biberach, Germany) 
17:50 Scale down of industrial scale fermentors using Euler-Lagrange CFD: A penicillin case study (L10)
Cees Haringa (TU Delft, The Netherlands)
18:05 A modelling framework for bioreactor simulations connecting physical and biological heterogenities (L11)
Jérôme Morchain (Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés, Toulouse, France)
18:20 Investigation of scale-up effects on mammalian cell culture process performance and critical quality attributes (L12)
Matthias Brunner (TU Wien, Austria)
18:30 Keynote lecture: Modelling populations of microorganisms – The Anaerobic Digestion Model No. 1 as an example (L13)
Krist V. Gernaey (Technical University of Denmark DTU, Lyngby, Denmark)
19:00 Key note lecture: Need for speed: Tools for enhanced microbial bioprocess development (L14)
Marco Oldiges (Forschungszentrum Jülich / Institute of Bio- and Geosciences- IBG-1:Biotechnology, Jülich, Germany)
Poster session, Exhibition and Welcome Reception at the conference venue   

Thursday, April 7, 2016

Session: Metabolic adaptation and population dynamics
Session chair: Marco Oldiges (Forschungszentrum Jülich, Germany), Christian Reitz (TU Berlin, Germany)
9:00 Key note lecture: Impacts of large-scale gradients mirrored on metabolic and transcriptional regulation (L15)
Ralf Takors (University of Stuttgart, Stuttgart, Germany)
9:30 Rapid feast-famine cycles for studying metabolic response and adaptation representative for large-scale (L16)
Liang Wu (DSM, Delft, The Netherlands) 
9:50 Metabolic regulation of carbon metabolism: Key element for robustness to bioreactor inhomogeneities (L17)
Michael Limberg (Forschungszentrum Jülich / Institute of Bio- and Geosciences- IBG-1:Biotechnology, Jülich, Germany)
10:05 Fermentation process gradient effect on C. glutamicum 1945 ΔACT3 PTUF-LDCCOPT producing cadaverine (L18)
Williams Olughu (Loughborough University, Loughborough, UK)
10:20 Performance loss of Corynebacterium glutamicum cultivations under scale-down conditions (L19)
Anja Lemoine (TU Berlin, Bioprocess Engineering, Germany)
10:35 Studies on the clavam biosynthetic pathway: a controling step for clavulanic acid production (L20)
Howard Ramirez-Malule (Grupo de Bioprocesos, Departamento de Ingeniería Química, Universidad de Antioquia UdeA, Medellín,Colombia)
Sponsor talk:Single-use online capacitance biomass measurement supporting process scale-up from 10L to 1000L in cell culture application (L21)
Stuart Tindal (Sartorius Stedim Biotech GmbH, Göttingen, Germany)
11:00 Coffee break and poster session and exhibition
11:40 Key note lecture: Exploiting the heterogeneity of biotic and abiotic phase in order to increase bioprocess robustness : toward new bioreactor design (L22)
Frank Delvigne (University of Liege, Belgium)
12:10 Multiparameter monitoring of gradients in the liquid phase of fermentation processes (L23)
Anika Bockisch (TU Berlin, BVT)
12:25 Quantification of spatial heterogeneity in large bioreactors (L24)
Anders Nørregaard (Department of Chemical and Biochemical Engineering, DTU, Lyngby, Denmark)
12:40 Sponsor talk: Connected in situ measurement system (L25)
Yoann Gasteuil (Céline Vinson, smartINST, Lyon, France)
12:50 Sponsor Talk: Optical sensors for bioprocess development and control (L26)
Gernot John (PreSens Precision Sensing, Regensburg, Germany)
12:55 Lunch break, poster session and exhibition
Session: Scale down approaches and process analytical technologies for advanced process design
Chair: Krist Gernaey (Technical University of Denmark DTU, Lyngby, Denmark), Stefan Junne (TU Berlin, Berlin, Germany)
14:00 Key note lecture: Bioprocesses under magnification: Learning from single cells about large-scale processes (L27)
Alexander Grünberger (Jülich Research Center, Germany)
14:30 Development of a perfusion system in a microbioreactor using sedimentation as a scale down tool for ATF perfusion bioreactors (L28)
Steffen Kreye (Glycotope GmbH, Berlin, Germany)
14:45 Key note lecture: Issues that are relevant when scaling-up hMSC microcarrier production processes in stirred bioreactor (L29)
Regine Eibl (ZHAW, Wedenswil, Switzerland)
15:15 Sponsor talk: Evaluation of a stirred small scale single-use bioreactor for microbial applications (L30)
Thomas Dreher (Sartorius Stedim Biotech GmbH, Göttingen, Germany)
15:25 Scalability of cultivations in the 2-dimensional rocking single-use bioreactor CELL-tainer (L31)
Anna-Maria Marbà-Ardébol (TU Berlin, Germany)
15:40 Towards efficient microaerobic processes using engineered Escherichia coli strains (L32)
Alvaro R. Lara and Karim Jaen (Universidad Autónoma Metropolitana-Cuajimalpa (UAM), México)
16:10 Coffee break and poster session and exhibition
16:50 Keynote Lecture: Novel fluorescence-based on-line capable monitoring of cell cycle distribution and growth rate for mammalian cell cultures (L33)
Grischa Fuge, An-Ping Zeng (TU Hamburg, Harburg, Germany)
17:20 Multiposition sampling, multiparameter monitoring and electrooptical tracking of microbial activity: New tools for better understanding biogas production (L34)
Erich Kielhorn (TU Berlin), Jörn Beheim-Schwarzbach (IASP Berlin, Germany)
17:45 In-line photon density wave spectroscopy for bioprocess monitoring (L35)
Roland Hass (University of Potsdam, Germany)
18:00 Key note lecture: Stirred, not shaken; unsolved issues and new problems in scale-down for scale-up (L36)
Alvin W. Nienow (Department of Chemical Engineering, University of Birmingham, UK)
19:30 Conference Dinner: Restaurant Zillemarkt, Berlin.Charlottenburg

Friday, April 8, 2016

Session: Quality by design in bioprocess development 
Chair: Ralf Takors (University of Stuttgart, Stuttgart, Germany), Erich Kielhorn (TU Berlin, Berlin, Germany)
9:00 Key note lecture: Next Generation mAb Production: Continuous Manufacturing, PAT, and Real Time Release (L37)
Douglas Richardson (Merck, USA)
9:30 Key note lecture: High-level protein production with Pichia: case studies of development path from strain generation over bioreactor (L38)
Roland Weis (VTU Technology GmbH, Grambach, Austria)
10:00 Key note lecture: ESETEC 2.0, a new, secretory E. coli strain for the production of complex recombinant proteins at industrial scale (L39)
Guido Seidel (Wacker Biotech, Jena, Germany)
10:30 Different process strategies for the Glutathione overproduction in Saccharomyces cerevisiae (L40)
Martin Senz (Research and Teaching Institute for Brewing in Berlin (VLB), Berlin, Germany)
10:50 Coffee break with poster session and exhibition
11:40 Key note lecture: Parallel small-scale bioreactors with on-line monitoring to prove the consistency of medium ingredients and pre-cultures and to efficiently assess process characteristics (L41)
Jochen Büchs (RWTH Aachen, Germany)
12:10 Towards intensifying design of experiments: An industrial E. coli feasibility study (L42)
Moritz von Stosch (Newcastle University, UK) 
12:30 Robot based bioprocess development by automated on-line optimal re-design in parallel bioreactors (L43)
M. Nicolas Cruz-Bournazou (TU Berlin, Berlin, Germany)
12:45 Plenary lecture: From advanced PAT to QbD-compliant quasi-continuous integrated pharmaceutical production (L44)
Rainer Luttmann (Research Center of Bioprocess Engineering and Analytical Techniques Hamburg University of Applied Sciences, Germany)
13:30 Concluding remarks
Peter Neubauer (TU Berlin, Germany)
13:45 End of symposium

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Exhibitors BioProScale Symposium 2016