5th BioProScale Symposium 2018

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Tuesday Wednesday Thursday

Tuesday, March 20, 2018

Historical Lecture Hall (2nd Floor)

12:00 Beginn registration  
13:00 Welcome address and introduction
Peter Neubauer, Department of Bioprocess Engineering, TU Berlin, Germany
13:20 Accelerated process development: How cell culture automation takes upstream process development to the next Level (L01)
Carsten Musmann, Roche Diagnostics GmbH, Penzberg, Germany
14:05 Short break  
Session 1A: Industrial Scale Biotechnology
Chair: Sjef Cornelissen / Peter Neubauer  
14:15 Keynote talk: From pilot to production: scaling industrial fermentation processes for enzyme production (L02)
Sjef Cornelissen, Novozymes A/S, Copenhagen, Danmark
14:45 Investigation of population heterogeneity caused by insufficient mixing in large-scale bioreactors (L03)
Alexander Niess, University of Stuttgart, Germany
15:05 Response of Yarrowia lipolytica to physico-chemical oscillations: understating the cross-link between glucose availability and morphology (L04)
Asma Timoumi, Université de Toulouse, France
15:25 Metabolic diversity of 1,4-butanediol producing E. coli with respect to oxygen oscillations (L05)
Viola Pooth, Forschungszentrum Jülich, Germany
15:45 Industry talk  
15:50 Coffee break and poster session and exhibition  
Session 2A: Industrial Scale Biotechnology
Chair: Sjef Cornelissen / Peter Neubauer  
16:35 Keynote talk: Bioprocess optimization through yeast-derived nutrients selection is critical for probiotics industrial manufacturing (L10)
Alain Sourabié, Procelys (Lesaffre Group), Maisons-Alfort, France
17:05 Pragmatic scale-down approaches in downstream processes for shortening innovation cycles in industrial biotechnology (L11)
Sven Hansen, Evonik Technology and Infrastructure GmbH, Germany
17:25 Flexible biotechnology production – considering variable upstream options (including transgenic plants and cell based) and innovative downstream Technology (L12)
Dirk Steinhäuser, Glatt Ingenieurtechnik GmbH, Germany
17:45 Integrated product and process development to produce a cold-water protease for liquid laundry products (L13)
Antony Calabria, DuPont
18:05 Total process integration of upstream and downstream processing of monoclonal antibodies (L14)
Martin Kornecki, Clausthal University of Technology, Germany
18:25 Industrial scale-up of the production of low cost poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in Halomonas bluephagenesis TD40 based on “blue-biotechnology “via cell-growth adapted fermentation process optimization (L15)
Jianwen Ye, Tsinghua University Beijing, China
18:45 L16 cancelled  
19:05 Industry talk
19:10 Industry talk
Evening Programme  
Poster session, Exhibition and Welcome Reception at the conference venue   

Bernhard von Langenbeck Hall (1st floor)

Session 1B: Bioprocess Development
Session chair: Marco Oldiges / Matthias Gimpel
14:15 Keynote talk: Design of novel Pichia pastoris promoters with high performance in methanol-free fed batch (L06)
Brigitte Gasser, BOKU Wien, Austria
14:45 Effect of the different strain production kinetics in Bioprocess Development for recombinant protein production with Pichia pastoris (L07)
Xavier Garcia-Ortega, Universitat Autònoma de Barcelona, Spain
15:05 Model-based prediction of temperature and pH shift to increase volumetric productivity of a CHO cell Fed-Batch process (L08)
Katrin Paul, TU Wien, Austria
15:25 Stable animal cell growth in perfusion processes: Using on-line permittivity sensors to control cell-specific perfusion rates (L09)
Alexander Nikolay, Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg, Germany
15:45 Industry talk
15:50 Coffee break and poster session and exhibition
Session 2B: Special Session ITN Rapid Bioprocess Development
Chair: Timo Hardiman / Stefan Junne
16:35 Mechanistic models for design, monitoring, and control (L17)
Krist Gernaey,  Technical University of Denmark, Denmark
17:05 Scaling down further: model-based study of scale-up effects in minibioreactors (L18)
Emmanuel Anane, TU Berlin, Germany
17:25 Bioprocess scale-down strategy based on a novel automated CFD based  compartmentalization technique (L19)
Gisela Nadal-Rey, Technical University of Denmark, Denmark
17:45 pH gradients in a 700 L lactic acid bacteria cultivation: validation of computational fluid dynamic and compartment modelling (L20)
Robert Spann, Technical University of Denmark, Denmark
18:05 Cocci chain length distribution of Streptococcus thermophilus: suitable gradient-induced stress indicator and scaling parameter (L21)
Klaus Pellicer Alborch, TU Berlin, Germany
18:25 A CFD model for the investigation of the sublimation phenomena during freeze-drying of lactic acid starter cultures (L22)
Teresa Melo de Carvalho, Technical University of Denmark, Denmark
18:45 Moving bioprocessing into the cloud and towards big data – the first steps (L23)
Eric Abellan, Infors AG
19:05 Industry talk
19:10 Industry talk
19:15  Poster session, Exhibition and Welcome Reception at the conference venue 
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